A-One oral Suspension 60 ml

Indications:
A- One Suspension solve fever, mild to moderate pain, neuropathic pain, headache, toothache, earache, body ache, colic pain, chronic back pain, inflammatory pain, post-vaccination pain and fever of children. Rheumatism and osteoarthritic joint pain, renal stone and migraine pain.

Dosage and Administration:

Dosage of Tablet:
Dosage of adult: 1-2 tablets every 4 to 6 hours maximum 4 gm (8 tablets) daily.
Dosage of Children: (6-12 years): ½ to 1 tablet 3 to 4 times daily.
Dosage of Extended release [XR] Tablet:
Dosage of Children over 12 years: 2 Tablets swallowed whole every 6 to 8 hours (maximum 6 tablets in any 24 hours). The tablet should not be crushed.
Dosage of the Suspension/Syrup:
Dosage of Children: under 3 months: 10 mg / kg body weight (reduce jaundice to 5 mg / kg) 3 to 4 times a day.
Dosage of Children: 3 Months to below 1 year: ½ to 1 teaspoon 3 to 4 times daily.
Dosage of Children: 1-5 Years: 1-2 measuring spoonful 3 to 4 times daily
Dosage of Children: 6-12 Years: 2- A measuring spoonful 3 to 4 times daily
Dosage of adult: 4-8 measuring spoonful 3 to 4 times daily
Dosage of the suppository:
Dosage of Children: 3 months to 1 year: 60-120 mg. 4 times daily
Dosage of Children: 1 to 5 years: 125- 250 mg. 4 times daily
Dosage of Children: 6 to 12 years: 250- 500 mg 4 times daily
Dosage of adult and Children over 12 years: 0.5-1-gm. 4 times daily
Dosage of Paediatric Drop:
Dosage of Children Up to 3 months: 0.5 ml [40 mg]
Dosage of Children 4 to 11 months: 1.0 ml [80]
Dosage of Children 7 to 2 years: 1.5 ml [120 mg] Do not change the dosage without advice of a doctor.

Side effect:

Thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis, pain at the site of inj and burning sensation. Rarely, hypotension and tachycardia.
Potentially fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, acute renal tubular necrosis, and hepatotoxicity.

Pharmacology:

A-One Suspension is the composition of paracetamol (Acetaminophen) which is the safest and most widely used painkiller and antipyretic. A-One produces analgesic action by increasing the pain threshold and antipyretics through action in the hypothalamic heat regulatory center. A-One has significantly mild side effects and is less likely to cause many serious side effects related to aspirin and other NSAIDs. Paracetamol is rapidly and completely absorbed from the GIT after oral administration and from the rectum after rectal administration. The average half-life of absorption from the upper small intestine is only 7 minutes. The drug is widely metabolized in the liver and has a plasma half-life of 1.5 to 3.0 hours. Paracetamol is not bound to plasma proteins to any extent. Paracetamol infusion provides pain relief within 5 to 10 minutes of starting administration. Peak The analgesic effect is found within 1 hour and the duration of this effect is usually 4 to 6 hours. Paracetamol infusion reduces fever within 30 minutes of starting administration with a duration of at least 6 hours antipyretic effect.

Overdose:

Symptoms of paracetamol overdose include paleness, nausea, vomiting, loss of appetite and abdominal pain. Liver damage may become apparent 12-48 hours after taking paracetamol. Hepatic failure in severe poisoning Encephalopathy can cause coma and death.